This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
Clonality
polyclonal
Host
Rabbit
Immunogen
L-selectin
Immunogen Region
L-selectin
Isotype
IgG
Molecular Weight
74 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
Synonyms
SELL, CD62L, LAM1, LECAM1, LEU8, LNHR
Uniprot
P14151
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10510.pdf" target="_blank">Data Sheet</ a>