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Home / Primary Antibodies / Polyclonal Antibodies

KLF4 antibody

SKU : BHA10804594

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Mfr.No.	FNab04602
Alternative Names	EZF ; GKLF
Background	This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
Host	Rabbit
Immunogen	Kruppel-like factor 4 (gut)
Isotype	IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	EZF, GKLF

Uniprot	O43474
Gene Id	9314
Research Area	Developmental biology, Metabolism, Cardiovascular, Stem Cells, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IP, IF, WB
Description	ELISA ; IHC ; IP ; IF ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04602.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804594	FNab04602	100ug	$240		Add to Cart

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