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Home / Primary Antibodies / Monoclonal Antibodies

KCC2 Antibody, Clone S1-12 - SMC-392

BHA11903355
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+1 866.986.9598
Email
[email protected]
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Swissprot Q63633
Accession Number NP_599190
Gene Id 171373
Target KCC2
Clone No S1-12
Research Area Pumps/Transporters, Ion Pumps/Transporters, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:300), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background KCC2 is a member of the cation-chloride cotransporter gene family (1). It acts as a K-Cl cotransporter. KCCs normally lower intracellular chloride concentrations below the electrochemical equilibrium potential and depending on the chemical concentration gradients of potassium and chloride, KCC2 can operate as a net efflux or influx pathway. It is proposed to act as the main chloride extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain (2, 3). KCC2 is expressed at high levels in neurons throughout the nervous system and immunofluorescence shows that the protein is localized at inhibitory synapses of the spinal cord (4). Studies in mice have shown that KCC2 reduces GABA's inhibitory signaling, resulting in motor defects, epilepsy, and anxiety-like behavior.
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~140kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP
Dilution WB (1:1000), IHC (1:300), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Lee L.H., Walker J.A., Williams J.R., Goodier R.J., Payne J.A., Moss S.J. (2007) J Biol Chem. 282(41): 29777-29784.

2. Watanabe M., Wake H., Moorhouse A.J., Nabekura J. (2009) J Biol Chem. 284(41): 27980-27988.

3. Gulyas A.I., Sik A., Payne J.A., Kaila K., Freund T.F. (2001) Eur J Neurosci. 13(12): 2205-2217.

4. Vinay L., Jean-Xavier C. (2008) Brain Res Rev. 57(1): 103-110.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11903355-1 SMC-392D Unconjugated 100 ug $330
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BHA11903355-2 SMC-392D-A390 ATTO 390 100 ug $384
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BHA11903355-3 SMC-392D-A488 ATTO 488 100 ug $383
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BHA11903355-4 SMC-392D-A594 ATTO 594 100 ug $383
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BHA11903355-5 SMC-392D-ALP Alkaline Phosphatase 100 ug $376
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BHA11903355-6 SMC-392D-APC APC 100 ug $382
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BHA11903355-7 SMC-392D-BI Biotin 100 ug $378
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BHA11903355-8 SMC-392D-FITC FITC 100 ug $374
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BHA11903355-9 SMC-392D-HRP HRP 100 ug $370
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BHA11903355-10 SMC-392D-PCP PerCP 100 ug $382
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BHA11903355-11 SMC-392D-RPE RPE 100 ug $380
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BHA11903355-12 SMC-392S Unconjugated 12 ug $44
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