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Home / Primary Antibodies / IHC Antibodies

JAK1 Antibody

SKU : BHA10559284

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA279447
Alternative Names	EC 2.7.10.2; JAK-1; JAK1; JAK1A; Janus kinase 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.Wilks A.F., Mol. Cell. Biol. 11:2057-2065(1991).Lee S.-T., Oncogene 8:3403-3410(1993).Lindholm C.K., Biochem. Biophys. Res. Commun. 296:929-936(2002).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human JAK1.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. Wilks A.F., Mol. Cell. Biol. 11:2057-2065(1991). Lee S.-T., Oncogene 8:3403-3410(1993). Lindholm C.K., Biochem. Biophys. Res. Commun. 296:929-936(2002).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total JAK1 protein.
Subcellular Location	Endomembrane system, Peripheral membrane protein

Uniprot	P23458
Gene Id	3716
Database Links	HGNC:6190 OMIM:147795 KEGG:hsa:3716 STRING:9606.ENSP00000343204 UniGene:Hs.207538
Function	Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway
Pathway	Jak-STAT signaling pathway PI3K-Akt signaling pathway Necroptosis Signaling pathways regulating pluripotency of stem cells NOD-like receptor signaling pathway Osteoclast differentiation Th1 and Th2 cell differentiation Th17 cell differentiation
Protein Families	Protein kinase superfamily, Tyr protein kinase family, JAK subfamily
Tissue Specificity	Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Weight	130 KDa

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IHC, IF

Description

ELISA ; IHC ; IF, IF ; ELISA ; IHC

Dilution

IHC	1:50-1:100
IF	1:100-1:500

Tested Application

ELISA,IHC,IF;IHC:1:50-1:100,IF:1:100-1:500

Datasheet
ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559284	CSB-PA279447	100ul	$297		Add to Cart

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