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Home / Primary Antibodies / Polyclonal Antibodies

Integrin beta 3 Antibody - SPC-1326

BHA11918054
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
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Swissprot P05106
Accession Number NP_000203.2
Gene Id 3690
Target Integrin beta 3
Research Area Cell adhesion, Cardiovascular System, Angiogenesis, Cardiovascular Growth Factors, Adhesion / Extracellular Matrix, Integrins, Cell Signaling, Blood, Platelets, Cytoskeleton
Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Dilutions WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Scientific Background Integrin beta-3 (beta3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. It associates with the integrin alpha_v chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin alpha_IIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of alpha_v/beta_3 integrin or vitronectin receptor to CD31 (PECAM-1). The 2C9.G2 antibody reacts with mouse and rat CD61, and is able to block ligand binding.
Shipping Temperature Blue Ice or 4°C
Specificity Detects endogenous levels of total Integrin beta3
Storage -20ºC
Storage Buffer PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications IHC, WB
Description WB ; IHC
Dilution WB (1:2000), IHC (1:200); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Sosnoski DM. et al. (1988) J Clin Invest 81 (6): 1993–8.

2. May, K. E. et al. (2011) Human Reproduction Update 17 (5): 637–653.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11918054-1 SPC-1326D Unconjugated 100 ul $286
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BHA11918054-2 SPC-1326D-A390 ATTO 390 100 ul $340
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BHA11918054-3 SPC-1326D-A488 ATTO 488 100 ul $339
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BHA11918054-4 SPC-1326D-A594 ATTO 594 100 ul $339
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BHA11918054-5 SPC-1326D-BI Biotin 100 ul $334
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BHA11918054-6 SPC-1326D-FITC FITC 100 ul $330
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