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Home / Primary Antibodies / Polyclonal Antibodies

IL21 antibody

SKU : BHA10804244

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Mfr.No.	FNab04251
Background	This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Host	Rabbit
Immunogen	interleukin 21
Isotype	IgG
Molecular Weight	18 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CVID11

Uniprot	Q9HBE4
Gene Id	59067
Research Area	Developmental biology, Immunology, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab04251.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804244	FNab04251	100ug	$280		Add to Cart

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