Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.Parnet P., J. Biol. Chem. 271:3967-3970(1996).Ota T., Nat. Genet. 36:40-45(2004).Hillier L.W., Nature 434:724-731(2005).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human IL18R.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
Parnet P., J. Biol. Chem. 271:3967-3970(1996). Ota T., Nat. Genet. 36:40-45(2004). Hillier L.W., Nature 434:724-731(2005).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total IL18R protein.
Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable)
Pathway
TNF signaling pathway
Protein Families
Interleukin-1 receptor family
Tissue Specificity
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.