Rabbit Anti-Human IKKa (pThr179+pSer180) Polyclonal

Mfr.No.	SPC-998, SPC-998D, SPC-998D-A390, SPC-998D-A488, SPC-998D-A594, SPC-998D-BI, SPC-998D-FITC
Immunogen Species	Human
Alternative Names	Chuk Antibody, CHUK1 Antibody, Conserved Helix Loop Helix Ubiquitous Kinase Antibody, I Kappa B Kinase 1 Antibody, IkB kinase alpha subunit Antibody, IkBKA Antibody, IKK 1 Antibody, IKK A Antibody, IKKA Antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells Antibody, NFKBIKA Antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha Antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor Antibody, TCF16 Antibody, Transcription factor 16 Antibody
Antigen	IKKa
Categories	Antibodies
Cellular Localization	Cytoplasm, Nucleus
Certificate Of Analysis	A 1:250 dilution of SPC-998 was sufficient for detection of IKKa (pThr179+pSer180) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Conjugate	Unconjugated, ATTO 390, ATTO 488, ATTO 594, Biotin, FITC
Description	Rabbit Anti-Human IKKa (pThr179+pSer180) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Thr179 and Ser180 of human IKKa (AA177-184), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Thr179 and Ser180 of human IKKa (AA177-184)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Widely expressed.

Swissprot	O15111
Accession Number	NP_001269
Gene Id	1147
Target	IKKa (pThr179+pSer180)
Research Area	Cell Signaling, Epigenetics and Nuclear Signaling, Nuclear Signaling Pathways, NFkB Pathway, IKK, Protein Phosphorylation, Serine / Threonine Kinases, Cardiovascular System, Atherosclerosis, Vascular Inflammation, Inflammatory Mediators, Immunology, Innate Immunity, TLR Signaling, Cancer, Apoptosis, Intracellular

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Widely expressed.
Scientific Background	IKKa is a protein-serine/threonine kinase. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Loss of function therefore blunts the NF-kB response. Cells with DNA damage are unable to undergo apoptosis. Oncogenesis may therefore occur indirectly by inhibitting a downstream tumour suppresor (inhibitors of NF-kB).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 84.654 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11912780-1	SPC-998D	Unconjugated	100 ul	$331	Add to Cart
BHA11912780-2	SPC-998D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11912780-3	SPC-998D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11912780-4	SPC-998D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11912780-5	SPC-998D-BI	Biotin	100 ul	$380	Add to Cart
BHA11912780-6	SPC-998D-FITC	FITC	100 ul	$375	Add to Cart

IKKa Antibody (pThr179+pSer180) - SPC-998

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