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Home / Antibodies

HPV-16 E1/E4 Antibody (V8338)

SKU : BHA17117926

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NSJ Bioreagents

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Mfr.No.	V8338, V8338-20UG, V8338-100UG
Clonality	Monoclonal
Description	The human papilloma virus (HPV) family of DNA tumor viruses includes HPV16, a 'high-risk' sexually-transmitted HPV that can lead to cervical, anal, vulvar, head, neck, and penile cancer. The HPV16E1/E4 protein is expressed abundantly in cells supporting viral DNA amplification, but is lost during malignant progression. HPV16E1/E4 causes G2 cell cycle arrest by associating with and preventing the nuclear entry of Cdk1/cyclin B1 complexes. HPV16E1/E4 also interacts with cyclin A and Cdk2 during the G2 phase of the cell cycle, and this association may increase the efficiency with which HPV16E1/E4 is able to prevent mitotic entry. HPV16E1/E4 also associates with keratin intermediate filaments and causes the network to collapse.
Formulation	0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Mouse
Immunogen Region	A recombinant human HPV16 E1/E4 fragment (amino acids 36-41) was used as the immunogen for this HPV16 E1/E4 antibody.
Isotype	IgG1,kappa
Predicted Reactivity	Type 16 of Human Papilloma Virus (HPV-16).
Reactivity	Type 16 of Human Papilloma Virus (HPV-16)
Recombinant	No
Subcellular Location	Nuclear

Clone No	HPV16 E1/E4

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity chromatography
Storage	Store the HPV16 E1/E4 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17117926-1	V8338-20UG	20ug	$219		Add to Cart
BHA17117926-2	V8338-100UG	100ug	$499		Add to Cart

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