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Home / Antibodies

GSK3 beta Antibody / GSK3B

SKU : BHA17102613

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NSJ Bioreagents

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Mfr.No.	F54007
Clonality	Monoclonal
Description	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. (UniProt)
Formulation	Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host	Mouse
Immunogen Region	A recombinant partial protein was used as the immunogen for this GSK3B antibody.
Isotype	IgG2a
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No

Uniprot	P49841
Clone No	2E6-D6-C12

Format	Purified
Purification	Protein G affinity
Storage	Store the GSK3B antibody at -20°C.

Applications	WB, ICC, IF, IP
Dilution	Western blot: 1:1000,ICC/Immunofluorescence: 1:200,Immunoprecipitation: suitable

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17102613	F54007	0.1 ml	$379		Add to Cart

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