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Home / Antibodies

GSK3 beta Antibody / GSK3B (F54007)

SKU : BHA17119906

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NSJ Bioreagents

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Mfr.No.	F54007-0.1ML
Clonality	Monoclonal (mouse origin)
Description	Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. (UniProt)
Formulation	Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host	Mouse
Immunogen Region	A recombinant partial protein was used as the immunogen for this GSK3B antibody.
Isotype	Mouse IgG2a
Species Reactivity	Human, Mouse, Rat
Note	The stated application concentrations are suggested starting points. Titration of the GSK3B antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	P49841

Format	Purified
Purity	Protein G affinity
Storage	Store the GSK3B antibody at -20oC.

Applications	WB, ICC/IF, IP
Description	Western blot: 1:1000,ICC/Immunofluorescence: 1:200,Immunoprecipitation: suitable

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119906	F54007-0.1ML	0.1 ml	$379		Add to Cart

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