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Home / Primary Antibodies / Monoclonal Antibodies

GRP170 Antibody, Clone 6G7-2H5 - SMC-233

BHA11901904
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Tel
+1 866.986.9598
Email
[email protected]
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Swissprot Q9Y4L1
Accession Number NP_006389.3
Gene Id 10525
Target GRP170
Clone No 6G7-2H5
Research Area Cardiovascular System |Cell Signaling, Cancer, Heat Shock, Neurodegeneration, Epigenetics and Nuclear Signaling, Cell Signaling, Chaperone Proteins, ER Proteins, Invasion/microenvironment, Cancer Metabolism, Response to Hypoxia, Metabolism, Metabolism processes, Hypoxia, Neuroscience, Protein Trafficking
Buffer PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background GRP170, also known as ORP150, is the largest member of glucose-regulated Antibodys, and acts as a human chaperone Antibody. It is thought to play an important role in Antibody folding and secretion in the ER. Suppression of the Antibody is associated with accelerated apoptosis, therefore having an important cryoprotective role in hypoxia-induced cellular pertubation. This cryopotective role has led to an anti-tumor immune response, which will hopefully lead to therapeutic immunizations against cancers (1). GRP170 has also been shown to bind with dendritic cells and provide the danger signals to induce anti-tumor immune responses (2).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~170kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications WB, ICC/IF
Description WB ; ICC ; IF
Dilution WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Wang H., et al. (2014) Front Oncol. 4: 377.

2. Manjili M.H., et al. (2006) Immun. Cell Biol. 84: 203-208.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11901904-1 SMC-233D Unconjugated 100 ug $330
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BHA11901904-2 SMC-233D-A390 ATTO 390 100 ug $384
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BHA11901904-3 SMC-233D-A488 ATTO 488 100 ug $383
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BHA11901904-4 SMC-233D-A594 ATTO 594 100 ug $383
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BHA11901904-5 SMC-233D-ALP Alkaline Phosphatase 100 ug $376
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BHA11901904-6 SMC-233D-APC APC 100 ug $382
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BHA11901904-7 SMC-233D-BI Biotin 100 ug $378
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BHA11901904-8 SMC-233D-FITC FITC 100 ug $374
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BHA11901904-9 SMC-233D-HRP HRP 100 ug $370
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BHA11901904-10 SMC-233D-PCP PerCP 100 ug $382
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BHA11901904-11 SMC-233D-RPE RPE 100 ug $380
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BHA11901904-12 SMC-233S Unconjugated 12 ug $44
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