Rabbit Anti-Human ErbB2 (pTyr877) Polyclonal

Mfr.No.	SPC-969, SPC-969D, SPC-969D-A390, SPC-969D-A488, SPC-969D-A594, SPC-969D-BI, SPC-969D-FITC
Immunogen Species	Human
Alternative Names	ER Alpha antibody, ER Beta antibody, Era antibody, Erb antibody, Erb2 antibody, ESR antibody, ESR1 antibody, ESR1_HUMAN antibody, ESR2 antibody, ESRA antibody, ESRB antibody, Estr antibody, Estra antibody, Estradiol Receptor alpha antibody, ESTRB antibody, Estrogen receptor 1 (alpha) antibody, Estrogen Receptor 1 antibody, Estrogen receptor 2 (ER beta) antibody, NR3A1 antibody, NR3A2 antibody, Nuclear receptor subfamily 3 group A member 1 antibody, Nuclear receptor subfamily 3 group A member 2 antibody, RNESTROR antibody
Categories	Antibodies
Cellular Localization	Cytoplasm, Nucleus, Cell Membrane
Certificate Of Analysis	A 1:250 dilution of SPC-969 was sufficient for detection of ErbB2 (pTyr877) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human ErbB2 (pTyr877) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Tyr877 of human ErbB2 (AA874-880), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Tyr877 of human ErbB2 (AA874-880)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	P04626
Accession Number	NP_004439
Gene Id	2064
Target	ErbB2 (pTyr877)
Research Area	Cancer, Tumor Biomarkers, Oncoproteins, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, Tyrosine Kinases, Receptor Tyrosine Kinases

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	ErbB2 is a receptor-tyrosine kinase of the epidermal growth factor receptor family,that is activated upon binding NRG with ErbB3. NRG acts as an autocrine factor produced in ovarian carcinomas. ERBB2 needs a coreceptor for ligand binding. Activates MAPK and PI3K pathways and is involved in cell proliferation, prolonging and enhancing survival signals, differentiation and apoptosis. Amplification and overexpression of ERBB2 is associated with numerous cancers. The increase of ERBB2 protein in breast tumour can be up to 100-fold.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 137.91 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11912258-1	SPC-969D	Unconjugated	100 ul	$331	Add to Cart
BHA11912258-2	SPC-969D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11912258-3	SPC-969D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11912258-4	SPC-969D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11912258-5	SPC-969D-BI	Biotin	100 ul	$380	Add to Cart
BHA11912258-6	SPC-969D-FITC	FITC	100 ul	$375	Add to Cart

ErbB2 Antibody (pTyr877) - SPC-969

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