Mouse Anti-Human DUX4 Monoclonal IgG1

Mfr.No.	SMC-192, SMC-192D, SMC-192D-A390, SMC-192D-A488, SMC-192D-A594, SMC-192D-ALP, SMC-192D-APC, SMC-192D-BI, SMC-192D-FITC, SMC-192D-HRP, SMC-192D-PCP, SMC-192D-RPE, SMC-192S
Immunogen Species	Human
Alternative Names	Double homeobox 4 Antibody, Double homeobox 10 Antibody, DUX10 Antibody, Double homeobox protein 4/10 Antibody, DUX4L antibody, DUX4L1 antibody
Categories	Antibodies
Cellular Localization	Nucleus
Certificate Of Analysis	1 ug/ml of SMC-192 was sufficient for detection of DUX4 in 20 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary.
Clonality	Monoclonal
Description	Mouse Anti-Human DUX4 Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag, Homo Sapiens (Human)
Immunogen Region	C-terminal 76 amino acids of Human DUX4 with glutathione-s-transferase (gst) tag
Isotype	IgG1
Launch Date	2011/06/29
Net Weight (g)	0.1
Reactivity	Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Human

Swissprot	F5GZ66
Accession Number	NP_149418.3
Gene Id	22947
Target	DUX4
Clone No	P2B1
Research Area	Stem Cells, Mesenchymal Stem Cells, Myogenesis

Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~45kDa. No cross-reactivity with DUX4c.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Entrez Gene: Dux4 Double Homeobox, 4 2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162. 3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623. 4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653. 5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11901434-1	SMC-192D	Unconjugated	100 ug	$330	Add to Cart
BHA11901434-2	SMC-192D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11901434-3	SMC-192D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11901434-4	SMC-192D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11901434-5	SMC-192D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11901434-6	SMC-192D-APC	APC	100 ug	$382	Add to Cart
BHA11901434-7	SMC-192D-BI	Biotin	100 ug	$378	Add to Cart
BHA11901434-8	SMC-192D-FITC	FITC	100 ug	$374	Add to Cart
BHA11901434-9	SMC-192D-HRP	HRP	100 ug	$370	Add to Cart
BHA11901434-10	SMC-192D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11901434-11	SMC-192D-RPE	RPE	100 ug	$380	Add to Cart
BHA11901434-12	SMC-192S	Unconjugated	12 ug	$44	Add to Cart

DUX4 Antibody, Clone P2B1 - SMC-192