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Home / Antibodies

DOG1 Antibody / TMEM16A / ANO1 (V7453)

SKU : BHA17116278

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NSJ Bioreagents

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Mfr.No.	V7453, V7453-20UG, V7453-100UG
Clonality	Monoclonal
Description	Expression of DOG1/ANO1/TMEM16A protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. TMEM16A is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for TMEM16A has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of TMEM16A and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 2-101 from the human protein was used as the immunogen for this recombinant TMEM16A antibody.
Isotype	IgG,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	Yes
Subcellular Location	Cell Surface and Cytoplasmic

Uniprot	Q5XXA6
Gene Id	55107
Clone No	DG1/2831R

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein A affinity chromatography
Storage	Store the recombinant TMEM16A antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17116278-1	V7453-20UG	20ug	$219		Add to Cart
BHA17116278-2	V7453-100UG	100ug	$499		Add to Cart

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