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Home / Primary Antibodies / Polyclonal Antibodies

DDX58 antibody

SKU : BHA10802312

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Mfr.No.	FNab02318
Alternative Names	DDX58 ; DEADboxprotein58 ; DKFZp434J1111 ; DKFZp686N19181 ; FLJ13599 ; RIG1 ; RIGI
Background	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp(DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain(CARD). It is involved in viral double-stranded(ds) RNA recognition and the regulation of immune response.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'- triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety, blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK- related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV), Rhabdoviridae: vesicular stomatitis virus (VSV), Orthomyxoviridae: influenza A and B virus, Flaviviridae: Japanese encephalitis virus (JEV), hepatitis C virus (HCV), dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III, such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation, bacterial phagocytosis and in the regulation of cell migration.
Host	Rabbit
Immunogen	DEAD(Asp-Glu-Ala-Asp) box polypeptide 58
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Rat
Regulatory	RUO
Synonyms	DDX58, DEAD box protein 58, DKFZp434J1111, DKFZp686N19181, FLJ13599, RIG 1, RIG I

Uniprot	O95786
Gene Id	23586
Research Area	Immunology, Metabolism
Weight	101 kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000

Tested Application

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:200

Manual	FNab02318.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802312	FNab02318	100ug	$280		Add to Cart

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