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Home / Primary Antibodies

DC-SIGN Antibody (N1090)

SKU : BHA17103539

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NSJ Bioreagents

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Mfr.No.	N1090, N1090-25UG, N1090-100UG
Antigen	DC-SIGN
Clonality	Polyclonal
Description	DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.
Formulation	0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Rabbit
Immunogen Region	A recombinant protein fragment from human DC-SIGN was used as the immunogen for this antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse
Reactivity	Human, Mouse
Recombinant	No

Gene Id	30835

Buffer	1X PBS, pH 7.4
Concentration	0.5 mg/ml
Format	Purified
Purification	Protein A purified antibody
Storage	Aliquot the DC-SIGN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB
Dilution	Western blot: 2-5ug/ml

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17103539-1	N1090-25UG	25ug	$209		Add to Cart
BHA17103539-2	N1090-100UG	100ug	$419		Add to Cart

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