Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Cytokeratin 1 is a hetero-tetramer of two type I as well as two type II keratins, keratin-10 (KRT10). Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epithelia. Mutations in keratin 1 cause epidermolytic hyperkeratosis.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A recombinant full-length human Cytokeratin 1 protein was used as the immunogen for this CK1 antibody.
Isotype
Mouse IgG2a, kappa
Species Reactivity
Human, Rat
Note
Optimal dilution of the antibody should be determined by the researcher.
Format
Purified
Purity
Protein G affinity chromatography
Storage
Store the CK1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).