Cytochrome P450 2E1 Antibody

Mfr.No.	DF6883
Alternative Names	4-nitrophenol 2-hydroxylase ; CP2E1_HUMAN ; CPE1 ; CYP2E ; Cyp2e1 ; CYPIIE1 ; Cytochrome P450 2E1 ; Cytochrome P450 isozyme 3A ; Cytochrome P450 LM3A ; Cytochrome P450, family 2, subfamily e, polypeptide 1 ; cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 ; Cytochrome P450, subfamily IIE ; Cytochrome P450-ALC ; Cytochrome P450-J ; Cytochrome P450RLM6 ; EC 1.14.13.- ; EC 1.14.13.n7 ; Ethanol-inducible P450 ; Flavoprotein-linked monooxygenase ; MGC133529 ; Microsomal monooxygenase ; OTTHUMP00000020813 ; OTTHUMP00000046571 ; P450 ALC ; P450-J ; P450C2E ; P450J ; P450RLM6 ; Xenobiotic monooxygenase ;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
Immunogen	A synthesized peptide derived from human CYP2E1.
Molecular Weight	Observed Mol.Wt.: 57kDa. Predicted Mol.Wt.: 57kDa.
Reactivity	Human, Mouse, Rat
Specificity	CYP2E1 Antibody detects endogenous levels of total CYP2E1.
Subcellular Location	Endoplasmic reticulum membrane. Microsome membrane.

Uniprot

P05181

Gene Id

1571

Sequence

10	20	30	40	50
MSALGVTVAL	LVWAAFLLLV	SMWRQVHSSW	NLPPGPFPLP	IIGNLFQLEL
60	70	80	90	100
KNIPKSFTRL	AQRFGPVFTL	YVGSQRMVVM	HGYKAVKEAL	LDYKDEFSGR
110	120	130	140	150
GDLPAFHAHR	DRGIIFNNGP	TWKDIRRFSL	TTLRNYGMGK	QGNESRIQRE
160	170	180	190	200
AHFLLEALRK	TQGQPFDPTF	LIGCAPCNVI	ADILFRKHFD	YNDEKFLRLM
210	220	230	240	250
YLFNENFHLL	STPWLQLYNN	FPSFLHYLPG	SHRKVIKNVA	EVKEYVSERV
260	270	280	290	300
KEHHQSLDPN	CPRDLTDCLL	VEMEKEKHSA	ERLYTMDGIT	VTVADLFFAG
310	320	330	340	350
TETTSTTLRY	GLLILMKYPE	IEEKLHEEID	RVIGPSRIPA	IKDRQEMPYM
360	370	380	390	400
DAVVHEIQRF	ITLVPSNLPH	EATRDTIFRG	YLIPKGTVVV	PTLDSVLYDN
410	420	430	440	450
QEFPDPEKFK	PEHFLNENGK	FKYSDYFKPF	STGKRVCAGE	GLARMELFLL
460	470	480	490
LCAILQHFNL	KPLVDPKDID	LSPIHIGFGC	IPPRYKLCVI	PRS

Concentration	1mg/ml
Format	Liquid
Purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.