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Home / Antibodies

Cyclin D1 Antibody / CCND1 (V8651)

SKU : BHA17118419

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NSJ Bioreagents

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Mfr.No.	V8651, V8651-20UG, V8651-100UG
Antigen	Cyclin D1
Clonality	Monoclonal
Description	Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 270-295 fro the human protein was used as the immunogen for the recombinant Cyclin D1 antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	Yes
Subcellular Location	Nuclear

Uniprot	P24385
Clone No	CCND1/3370R

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein A affinity chromatography
Storage	Store the recombinant Cyclin D1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	IHC-P
Dilution	Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17118419-1	V8651-20UG	20ug	$219		Add to Cart
BHA17118419-2	V8651-100UG	100ug	$499		Add to Cart

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