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Home / Primary Antibodies / Monoclonal Antibodies

Cyclin D1 antibody

SKU : BHA10802118

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Mfr.No.	FNab02124
Background	CCND1(cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma(MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.
Categories	Primary Antibodies
Clonality	monoclonal
Host	Mouse
Immunogen	cyclin D1
Isotype	IgG2a
Molecular Weight	36 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	B cell lymphoma 1 protein, CCND1, cyclin D1, D11S287E, G1/S specific cyclin D1, PRAD1, PRAD1 oncogene, U21B31

Uniprot	P24385
Clone No	8E8
Research Area	Cell Division and Proliferation, Metabolism, Immunology, Cancer

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:2000-1:10000

Manual	FNab02124.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10802118	FNab02124	100ug	$260		Add to Cart

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