Rabbit Anti-Human Collagen I Polyclonal

Mfr.No.	SPC-1273, SPC-1273D, SPC-1273D-A390, SPC-1273D-A488, SPC-1273D-A594, SPC-1273D-BI, SPC-1273D-FITC
Immunogen Species	Human
Alternative Names	Alpha 1 type I collagen Antibody, Alpha 2 type I collagen Antibody, CO1A1_HUMAN Antibody, collagen alpha 1 chain type I Antibody, EDSC Antibody, Type I procollagen antibody
Categories	Antibodies
Cellular Localization	Extracellular matrix
Certificate Of Analysis	A 1:100 dilution of SPC-1273 was sufficient for detection of Collagen I in NIH/3T3 cells using Goat Anti-Rabbit IgG as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human Collagen I Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthesized peptide derived from N-terminal of human Collagen I., Homo Sapiens (Human)
Immunogen Region	Synthesized peptide derived from N-terminal of human Collagen I.
Isotype	IgG
Launch Date	2016/09/06
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.

Swissprot	P08123
Accession Number	NP_000080.2
Gene Id	1278
Target	Collagen I
Research Area	Cell Signaling, Extracellular Matrix (ECM), Collagen, Stem Cells, Mesenchymal Stem Cells, Osteogenesis

Buffer	PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide
Dilutions	IHC (1:100), ICC/IF (1:500), ELISA (1:5000); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
Scientific Background	Type-I collagen is the predominant form of collagen in the human body and plays a role in scar tissue formation. Collagen type 1 is also an important component of tendons and found in most connective tissues including cartilage. Collagen 1 is associated with several diseases including: Ehlers Danlos syndrome (arthrochalasia), Ehlers-Danlos syndrome (classical type), Osteogenesis imperfecta type 1-4 and osteoporosis.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~139kDa, endogenous levels of total Collagen I protein. Collage type I is a triple helix consisting of one alpha-2 and 2 alpha-1 chains, so dimeric (~270kDa) and trimeric (~400kDa) forms may be expected.
Storage	-20ºC
Storage Buffer	PBS pH 7.4, 50% glycerol, 150mM NaCl, 0.02% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	ELISA, IHC, ICC/IF
Description	IHC ; ICC ; IF ; ELISA
Dilution	IHC (1:100), ICC/IF (1:500), ELISA (1:5000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Stuart J.M., et al. (2005) Arthritis Rheum. 26(7): 832-840.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11917136-1	SPC-1273D	Unconjugated	100 ul	$286	Add to Cart
BHA11917136-2	SPC-1273D-A390	ATTO 390	100 ul	$340	Add to Cart
BHA11917136-3	SPC-1273D-A488	ATTO 488	100 ul	$339	Add to Cart
BHA11917136-4	SPC-1273D-A594	ATTO 594	100 ul	$339	Add to Cart
BHA11917136-5	SPC-1273D-BI	Biotin	100 ul	$334	Add to Cart
BHA11917136-6	SPC-1273D-FITC	FITC	100 ul	$330	Add to Cart

Collagen I Antibody - SPC-1273