Rabbit Anti-Human CLK1 (pSer337 + pThr338) Polyclonal

Mfr.No.	SPC-952, SPC-952D, SPC-952D-A390, SPC-952D-A488, SPC-952D-A594, SPC-952D-BI, SPC-952D-FITC
Immunogen Species	Human
Alternative Names	CDC like kinase 1 Antibody, CDC28/CDC2 like kinase Antibody, CLK Antibody, CLK/STY Antibody, CLK1_HUMAN Antibody, Protein tyrosine kinase STY Antibody, STY Antibody
Categories	Antibodies
Cellular Localization	Nucleus
Certificate Of Analysis	A 1:250 dilution of SPC-952 was sufficient for detection of CLK1 (pSer337 + pThr338) in 10 ug of 293T cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human CLK1 (pSer337 + pThr338) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Ser337 and Thr338 of human CLK1 (AA334-341), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Ser337 and Thr338 of human CLK1 (AA334-341)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human

Swissprot	P49759
Accession Number	NP_001155879
Gene Id	1195
Target	CLK1 (pSer337 + pThr338)
Research Area	Cell Signaling, Protein Phosphorylation, Tyrosine Kinases, Serine / Threonine Kinases, Epigenetics and Nuclear Signaling, DNA/RNA, RNA Processing

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Scientific Background	The CDC-like kinase 1 (CLK1) dually phosphorylates serine- and arginine-rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/thre-onine residues. CLK1 activity is negatively regulated by steric constraints mediated by the N-terminal domain and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 57.205 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11911952-1	SPC-952D	Unconjugated	100 ul	$331	Add to Cart
BHA11911952-2	SPC-952D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11911952-3	SPC-952D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11911952-4	SPC-952D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11911952-5	SPC-952D-BI	Biotin	100 ul	$380	Add to Cart
BHA11911952-6	SPC-952D-FITC	FITC	100 ul	$375	Add to Cart

CLK1 Antibody (pSer337 + pThr338) - SPC-952