binder of Rho GTPases 4; BORG4; CDC42 effector protein (Rho GTPase binding) 4; Cdc42 effector protein 4; CEP4
Antigen
CDC42EP4
Categories
Primary Antibodies
Clonality
polyclonal
Description
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.Osada N., J. Hum. Genet. 45:374-377(2000).Hirsch D.S., J. Biol. Chem. 276:875-883(2001).Olsen J.V., Cell 127:635-648(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human BORG4.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Osada N., J. Hum. Genet. 45:374-377(2000). Hirsch D.S., J. Biol. Chem. 276:875-883(2001). Olsen J.V., Cell 127:635-648(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total BORG4 protein.
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.
Protein Families
BORG/CEP family
Tissue Specificity
Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.