CD44 Antibody

Mfr.No.	BF9213
Alternative Names	LHR ; BA-1 ; CD 44 ; CD44 ; CD44 antigen ; CD44 molecule (Indian blood group) ; CD44 molecule ; CD44_HUMAN ; CDw44 ; Cell surface glycoprotein CD44 ; chondroitin sulfate proteoglycan 8 ; CSPG8 ; ECMR-III ; Epican ; Extracellular matrix receptor III ; GP90 lymphocyte homing/adhesion receptor ; HCELL ; hematopoietic cell E- and L-selectin ligand ; Heparan sulfate proteoglycan ; Hermes antigen ; homing function and Indian blood group system ; HSA ; HUTCH-I ; HUTCH1 ; Hyaluronate receptor ; IN ; INLU-related p80 Glycoprotein ; MC56 ; MDU2 ; MDU3 ; MGC10468 ; MIC4 ; MUTCH1 ; PGP-1 ; PGP-I ; PGP1 ; Phagocytic glycoprotein 1 ; Phagocytic glycoprotein I ; Soluble CD44 ;
Categories	Primary Antibodies
Clonality	monoclonal
Description	CD44, also known as IN, LHRMIC4, CDW44, HCELL. It is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Immunogen	Purified recombinant fragment of human CD44 (628-699) expressed in E. Coli.
Molecular Weight	Observed Mol.Wt.: 82kDa. Predicted Mol.Wt.: 82kDa.
Reactivity	Human, Mouse
Specificity	Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.
Subcellular Location	Membrane.

Uniprot

P16070

Gene Id

960

Sequence

10 20 30 40 50
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA
60 70 80 90 100
DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN
110 120 130 140 150
NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR
160 170 180 190 200
DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST
210 220 230 240 250
VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL
260 270 280 290 300
PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD
310 320 330 340 350
EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN
360 370 380 390 400
GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK
410 420 430 440 450
EQWFGNRWHE GYRQTPKEDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW
460 470 480 490 500
TDFFNPISHP MGRGHQAGRR MDMDSSHSIT LQPTANPNTG LVEDLDRTGP
510 520 530 540 550
LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS
560 570 580 590 600
EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR
610 620 630 640 650
SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW
660 670 680 690 700
LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN
710 720 730 740
GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV

Concentration	1mg/ml
Format	Liquid
Storage Condition	Ascitic fluid containing 0.03% sodium azide.This product will ship in a box containing blue ice at a temperature of 4°C.