May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.Jason S. Knight, J. Virol., Dec 2004; 78: 12857 - 12867.Motoo Katabami, J. Biol. Chem., Apr 2005; 280: 16728 - 16738.Karen E. Knudsen, J. Biol. Chem., Sep 1999; 274: 27632.Peng Ji, J. Biol. Chem., Aug 2006; 281: 24058 - 24069.
Host
Rabbit
Immunogen
Synthesized peptide derived from Human Cyclin A.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Jason S. Knight, J. Virol., Dec 2004; 78: 12857 - 12867. Motoo Katabami, J. Biol. Chem., Apr 2005; 280: 16728 - 16738. Karen E. Knudsen, J. Biol. Chem., Sep 1999; 274: 27632. Peng Ji, J. Biol. Chem., Aug 2006; 281: 24058 - 24069.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Cyclin A protein.
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Pathway
Cell cycle Cellular senescence AMPK signaling
Protein Families
Cyclin family, Cyclin AB subfamily
Tissue Specificity
Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.