Mouse Anti-Human beta 4 Spectrin Monoclonal IgG1

Mfr.No.	SMC-484, SMC-484D, SMC-484D-A390, SMC-484D-A488, SMC-484D-A594, SMC-484D-ALP, SMC-484D-APC, SMC-484D-BI, SMC-484D-FITC, SMC-484D-HRP, SMC-484D-PCP, SMC-484D-RPE, SMC-484S
Immunogen Species	Human
Alternative Names	BetaIV-spectrin sigma1 Antibody, Non-erythrocytic spectrin beta chain 4 Antibody, Non-erythroidspectrin beta chain 3 Antibody, SPTBN4 Antibody, SPTBN3 Antibody, Spnb4 Antibody, KIAA1642 Antibody, EMBL BAB83243.1 Antibody, Ensembl ENSRNOP00000028393 Antibody
Categories	Antibodies
Cellular Localization	Cytoskeleton, Cytoplasm, Cell Cortex
Certificate Of Analysis	A 1:100 dilution of SMC-484 was sufficient for detection of Beta 4 Spectrin in 20 ug of mouse brain lysate by ECL immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Clonality	Monoclonal
Description	Mouse Anti-Human beta 4 Spectrin Monoclonal IgG1
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Mouse
Gross Weight (kg)	1.4
Immunogen	Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin, Homo Sapiens (Human)
Immunogen Region	Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin
Isotype	IgG1
Launch Date	2015/03/10
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human

Swissprot	Q9H254
Accession Number	NP_066022.2
Gene Id	57731
Target	beta 4 Spectrin
Clone No	S393-2
Research Area	Cell Signaling, Scaffold Proteins, Neuroscience

Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); optimal dilutions for assays should be determined by the user.
Purification	Protein G Purified
Scientific Background	Spectrin is the major constituent of the cytoskeletal network underlying the erthrocyte plasma membrane and determines cell shape, arrangement of transmembrane proteins and organization of organelles. It is expressed at very low levels in many tissues, with the strongest expression in the cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder and heart (1). Spectrin beta 4 is a non-erythrocyte member, and is expressed in the brain and pancreatic islets and localisted to the nuclear matrix, cytoplasmic vesicles and PML nuclear bodies. Beta4 spectrins are also essential for membrane stability and the molecular organization of the nodes of Ranvier (2).
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~>200kDa. Does not cross react with other Beta-spectrins
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	IHC, WB, ICC/IF
Description	WB ; IHC ; ICC ; IF
Dilution	WB (1:1000); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Genes and mapped phenotypes. (n.d.). Retrieved March 12, 2015, from http://www.ncbi.nlm.nih.gov/gene/57731 2. Yang Y., Lacas-Gervais S., Morest D.K., Solimena M., and Rasband M.N. (2004) J Neurosci. 24(33): 7230-7240.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11905065-1	SMC-484D	Unconjugated	100 ug	$330	Add to Cart
BHA11905065-2	SMC-484D-A390	ATTO 390	100 ug	$384	Add to Cart
BHA11905065-3	SMC-484D-A488	ATTO 488	100 ug	$383	Add to Cart
BHA11905065-4	SMC-484D-A594	ATTO 594	100 ug	$383	Add to Cart
BHA11905065-5	SMC-484D-ALP	Alkaline Phosphatase	100 ug	$376	Add to Cart
BHA11905065-6	SMC-484D-APC	APC	100 ug	$382	Add to Cart
BHA11905065-7	SMC-484D-BI	Biotin	100 ug	$378	Add to Cart
BHA11905065-8	SMC-484D-FITC	FITC	100 ug	$374	Add to Cart
BHA11905065-9	SMC-484D-HRP	HRP	100 ug	$370	Add to Cart
BHA11905065-10	SMC-484D-PCP	PerCP	100 ug	$382	Add to Cart
BHA11905065-11	SMC-484D-RPE	RPE	100 ug	$380	Add to Cart
BHA11905065-12	SMC-484S	Unconjugated	12 ug	$44	Add to Cart

beta 4 Spectrin Antibody, Clone S393-2 - SMC-484