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Home / Antibodies

BCL2L1 (Ab-62) Antibody

SKU : BHA10557509

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA923588
Alternative Names	Apoptosis regulator Bcl-X
Categories	Primary Antibodies
Clonality	polyclonal
Description	Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis.Basu A, et.al.( 2003) Mar 13; 538(1-3): 41-7Cheng E.H.-Y. et.al. (1996) Nature 379:554-556.Sattler M. et.al. (1997), Science 275:983-986.Muchmore S.W.et.al (1996).Nature 381:335-341Yu J., Zhang L. Mol. (2001)Cell 7:673-682
Host	Rabbit
Immunogen	Peptide sequence around aa.60~64 (A-D-S-P-A) derived from Human BCL-XL .
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Potent inhibitor of cell death. Isoform Bcl-X(L) anti-apoptotic activity is inhibited by association with SIVA isoform 1. Inhibits activation of caspases By similarity. Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, cytochrome c, from the mitochondrial membrane. The Bcl-X(S) isoform promotes apoptosis. Basu A, et.al.( 2003) Mar 13; 538(1-3): 41-7 Cheng E.H.-Y. et.al. (1996) Nature 379:554-556. Sattler M. et.al. (1997), Science 275:983-986. Muchmore S.W.et.al (1996).Nature 381:335-341 Yu J., Zhang L. Mol. (2001)Cell 7:673-682
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total BCL-XL protein.
Subcellular Location	Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side

Uniprot	Q07817
Database Links	HGNC:992 OMIM:600039 KEGG:hsa:598 STRING:9606.ENSP00000302564 UniGene:Hs.516966
Function	Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION
Pathway	Jak-STAT signaling pathway PI3K-Akt signaling pathway NF-kappa B signaling pathway Apoptosis Autophagy Ras signaling pathway NOD-like receptor signaling pathway
Protein Families	Bcl-2 family
Tissue Specificity	Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557509	CSB-PA923588	100ul	$297		Add to Cart

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