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Home / Primary Antibodies / IHC Antibodies

BCL2 (Ab-56) Antibody

SKU : BHA10559617

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA187601
Alternative Names	BCL2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).Ling, Y. H. et al. (1998) J. Biol. Chem. 273, 18984-18991.Huang, S.J. and Cidlowski, J.A. (2002) FASEB 16, 825-832.Deng, X. et al. (2001) J. Biol. Chem. 276, 23681-23688.Huang ST,et al. (2002) FASEB J Jun; 16(8): 825-32.Yamamoto, K. et al. (1999) Mol. Cell. Biol. 19, 8469-8478.
Host	Rabbit
Immunogen	Peptide sequence around aa. 54~58 (G-H-T-P-H) derived from Human BCL-2.
Involvement In Disease	A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). Ling, Y. H. et al. (1998) J. Biol. Chem. 273, 18984-18991. Huang, S.J. and Cidlowski, J.A. (2002) FASEB 16, 825-832. Deng, X. et al. (2001) J. Biol. Chem. 276, 23681-23688. Huang ST,et al. (2002) FASEB J Jun; 16(8): 825-32. Yamamoto, K. et al. (1999) Mol. Cell. Biol. 19, 8469-8478.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total BCL-2 protein.
Subcellular Location	Mitochondrion outer membrane, Single-pass membrane protein, Nucleus membrane, Single-pass membrane protein, Endoplasmic reticulum membrane, Single-pass membrane protein

Uniprot	P10415
Gene Id	596
Database Links	HGNC:990 OMIM:151430 KEGG:hsa:596 STRING:9606.ENSP00000329623 UniGene:Hs.150749
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release
Pathway	Estrogen signaling pathway Hedgehog signaling pathway HIF-1 signaling pathway Jak-STAT signaling pathway PI3K-Akt signaling pathway Focal adhesion NF-kappa B signaling pathway Apoptosis Autophagy Necroptosis Protein processing in endoplasmic reticulum NOD-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications ER Stress pathway Neurotrophin signaling pathway
Protein Families	Bcl-2 family
Tissue Specificity	Expressed in a variety of tissues.
Weight	22,337 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF, WB ; ELISA ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:100-1:200

Tested Application

ELISA,WB,IHC,IF;WB:1:500-1:1000,IHC:1:50-1:200,IF:1:100-1:200

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559617	CSB-PA187601	100ul	$297		Add to Cart

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