Rabbit Anti-Human ATR (pSer435 + pSer436) Polyclonal

Mfr.No.	SPC-918, SPC-918D, SPC-918D-A390, SPC-918D-A488, SPC-918D-A594, SPC-918D-BI, SPC-918D-FITC
Immunogen Species	Human
Alternative Names	FRAP Related Protein 1 Antibody, MEC1 Antibody, RAC3 Antibody, SCKL Antibody
Categories	Antibodies
Cellular Localization	Nucleus, PML body
Certificate Of Analysis	A 1:250 dilution of SPC-918 was sufficient for detection of ATR (pSer435 + pSer436) in 10 ug of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human ATR (pSer435 + pSer436) Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	A phospho-specific peptide corresponding to residues surrounding Ser435 and Ser436 of human ATR (AA432-439), Homo Sapiens (Human)
Immunogen Region	A phospho-specific peptide corresponding to residues surrounding Ser435 and Ser436 of human ATR (AA432-439)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Human
Tissue Specificity	Ubiquitous

Swissprot	Q13535
Accession Number	NP_001175
Gene Id	545
Target	ATR (pSer435 + pSer436)
Research Area	Cell Signaling, Epigenetics and Nuclear Signaling, DNA/RNA, DNA Damage and Repair, ATM / ATR, Cancer, Cell Cycle, Tumor suppressors

Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions	WB (1:250); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Ubiquitous
Scientific Background	ATR is a protein-serine/threonine kinase. It is part of the PI3K family and functions in a complex with ATRIP. It responds to DNA damage and replication stresses and activates proteins that mediate DNA repair such as p53, BRCA1 and more. It other roles involve checkpoint signalling by interacting with chk1, fragile site stabilty and regulation of centrosome duplication.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects 301.367 kDa.
Storage	-20ºC
Storage Buffer	PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	AM, WB
Description	WB ; AM
Dilution	WB (1:250); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11911340-1	SPC-918D	Unconjugated	100 ul	$331	Add to Cart
BHA11911340-2	SPC-918D-A390	ATTO 390	100 ul	$385	Add to Cart
BHA11911340-3	SPC-918D-A488	ATTO 488	100 ul	$384	Add to Cart
BHA11911340-4	SPC-918D-A594	ATTO 594	100 ul	$384	Add to Cart
BHA11911340-5	SPC-918D-BI	Biotin	100 ul	$380	Add to Cart
BHA11911340-6	SPC-918D-FITC	FITC	100 ul	$375	Add to Cart

ATR Antibody (pSer435 + pSer436) - SPC-918