Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN9CCAC[GA]-3') when NF-Y is bound to ERSE.Min J., Genomics 30:149-156(1995).Khanna A., Biochem. J. 319:81-89(1996).Xie T., Genome Res. 13:2621-2636(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ATF6B.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN9CCAC[GA]-3') when NF-Y is bound to ERSE.
Min J., Genomics 30:149-156(1995). Khanna A., Biochem. J. 319:81-89(1996). Xie T., Genome Res. 13:2621-2636(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ATF6B protein.
Subcellular Location
Endoplasmic reticulum membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Processed cyclic AMP-dependent transcription factor ATF-6 beta: Nucleus
Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.