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Home / Antibodies

ASPSCR1 Antibody

SKU : BHA10557526

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA180850
Alternative Names	ASPL; RCC17; TUG; UBXD9; UBXN9
Categories	Primary Antibodies
Clonality	polyclonal
Description	Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.Ladanyi, M. et al. (2001) Oncogene 20, 48-57. Bogan, J.S. et al. (2003) Nature 425, 727-33. Yu, C. et al. (2007) J Biol Chem 282, 7710-22.
Host	Rabbit
Immunogen	Peptide sequence around aa.303 ~307(P-Q-Q-E-Q) derived from Human ASPSCR1.
Involvement In Disease	A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution. Ladanyi, M. et al. (2001) Oncogene 20, 48-57. Bogan, J.S. et al. (2003) Nature 425, 727-33. Yu, C. et al. (2007) J Biol Chem 282, 7710-22.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ASPSCR1 protein.
Subcellular Location	Endomembrane system, Peripheral membrane protein, Endoplasmic reticulum-Golgi intermediate compartment membrane, Peripheral membrane protein, Cytoplasm, Nucleus

Uniprot	Q9BZE9
Gene Id	79058
Database Links	HGNC:13825 OMIM:606236 KEGG:hsa:79058 STRING:9606.ENSP00000302176 UniGene:Hs.298351
Function	Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.
Tissue Specificity	Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.
Weight	60,183 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557526	CSB-PA180850	100ul	$297		Add to Cart

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