SERPINC1, also named Antithrombin III or Antithrombin, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Categories
Primary Antibodies
Cellular Localization
Secreted
Clonality
polyclonal
Description
SERPINC1, also named Antithrombin III or Antithrombin, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
Host
Rabbit
Immunogen
serpin peptidase inhibitor, clade C(antithrombin), member 1
Isotype
IgG
Molecular Weight
53 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Secreted
Synonyms
Antithrombin, Antithrombin III, AT3, ATIII, HEPARIN COFACTOR I, Serpin C1, SERPINC1
Uniprot
P01008
Research Area
Cardiovascular, Metabolism
Weight
53kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)