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Home / Antibodies

Anti-WT1-AS Antibody BHA11303217

SKU : BHA11303217

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Mfr.No.	BS60050
Alternative Names	Putative Wilms tumor upstream neighbor 1 gene protein ; WIT-1 ; Wilms tumor-associated antisense RNA ; WT1-AS ; WIT1
Antigen	WT1-AS
Categories	Primary Antibodies
Clonality	polyclonal
Description	Wilms’ tumor is a neoplasm of the kidneys that usually occurs in children and is characterized by the presence of abortive tubules and glomeruli surrounded by a spindled cell stroma. The 11p13 Wilms’ tumor locus consists of two coordinately regulated transcripts, WT1 and WIT-1, which are mutated in Wilms’ tumors. Wilms’ tumor upstream neighbor 1 (WIT-1) is encoded by an intron-less gene upstream of the Wilms’ tumor 1 (WT1) gene, which is is important for nephrogenesis and gonadal growth. The WT1 gene is bi-directionally transcribed from the same promoter region as WIT-1, which may function as an antisense regulator of WT1. WIT-1 and WT1 have the same temporal and cell-restricted expression pattern, although the expression of WIT-1 is less abundant. Methylation of the WIT-1 gene is implicated in hematologic malignancy of chemoresistant acute myeloid leukemia. Single nucleotide polymorphisms (SNPs) in the WIT-1 gene are significantly associated with focal segmental glomerulosclerosis.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human WT1-AS.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	Q06250
Uniprot	Q06250
Weight	15 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: WT1-AS polyclonal antibody detects endogenous levels of WT1-AS protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303217	BS60050	50µl	$190.44		Add to Cart
BHA11303217	BS60050	100µl	$294.44		Add to Cart

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