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Home / Antibodies

Anti-UCHL1 Antibody BHA11304264

SKU : BHA11304264

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Mfr.No.	BS61514
Alternative Names	Ubiquitin carboxyl-terminal hydrolase isozyme L1 ; UCH-L1 ; Neuron cytoplasmic protein 9.5 ; PGP 9.5 ; PGP9.5 ; Ubiquitin thioesterase L1 ; UCHL1
Antigen	UCHL1
Categories	Primary Antibodies
Chromosome Location	4p13
Clonality	polyclonal
Description	UCHL1 (PGP 9.5/PARK5) functions as a deubiquitinating enzyme and monoubiquitin stabilizer. In vitro studies have demonstrated that UCHL1 can hydrolyze isopeptide bonds between the carboxy-terminal glycine of Ub and the ε-amino group of lysine on target proteins. UCHL1 is also involved in the cotranslational processing of pro-ubiquitin and ribosomal proteins translated as ubiquitin fusions . Mice deficient in UCHL1 experience spasticity, suggesting that UCHL1 activity is required for the normal neuromuscular junction structure and function . Research studies have described loss of UCHL1 expression in numerous human malignancies, such as prostate, colorectal, renal, and breast carcinomas. Investigators have shown that loss of UCHL1 expression in breast carcinomas can be attributed to hyper-methylation of the UCHL1 gene promoter . While loss of UCHL1 expression is implicated in human carcinogenesis, mutation of UCHL1 has been implicated in neurodegenerative diseases such as Parkinson's and Alzheimer's .
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 49-93 of Human UCHL1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P09936
Uniprot	P09936
Weight	24, 27 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: UCHL1 polyclonal antibody detects endogenous levels of UCHL1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304264	BS61514	50µl	$190.44		Add to Cart
BHA11304264	BS61514	100µl	$294.44		Add to Cart

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