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Home / Primary Antibodies / IHC Antibodies

Anti-UBA7 Antibody BHA11300648

SKU : BHA11300648

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Mfr.No.	BS1486
Alternative Names	Ubiquitin-like modifier-activating enzyme 7 ; Ubiquitin-activating enzyme 7 ; D8 ; Ubiquitin-activating enzyme E1 homolog ; UBA7 ; UBE1L ; UBE2
Antigen	UBA7
Categories	Primary Antibodies
Chromosome Location	3p21.31
Clonality	polyclonal
Description	The ubiquitin activating enzyme E1 (UBE1) catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. UBE1 activates ubiquitin by first adenylating (with ATP) its carboxy-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and a free AMP. UBE1 is an example of an X-Y homologous gene, which is X-linked with a distinct Y-linked gene in many mammals. UBE1L (Ubiquitin-activating enzyme E1 homolog), also known as UBA7 (Ubiquitin-like modifier-activating enzyme 7) or UBE2, is a 1011 amino acid homolog of UBE1. Like UBE1, UBE1L functions in the activation of ubiquitin through ATP-dependent adenylation. UBE1L is expressed in tumor cells and is a retinoid target that, through conjugation with ISG15 (Interferon-induced 15 kDa protein), triggers degradation and apoptosis in acute promyelocytic leukemia.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids C-terminus of Human UBE1L.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P41226
Uniprot	P41226
Weight	112 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: UBE1L (E996) polyclonal antibody detects endogenous levels of UBE1L protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300648	BS1486	50µl	$190.44		Add to Cart
BHA11300648	BS1486	100µl	$294.44		Add to Cart

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