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Home / Antibodies

Anti-TXK Antibody BHA11304253

SKU : BHA11304253

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Mfr.No.	BS61497
Alternative Names	Tyrosine-protein kinase TXK ; Protein-tyrosine kinase 4 ; Resting lymphocyte kinase ; TXK ; PTK4 ; RLK
Antigen	TXK
Categories	Primary Antibodies
Chromosome Location	4p12
Clonality	polyclonal
Description	The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Emt (also known as Itk or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton’s disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 321-366 of Human TXK.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P42681
Uniprot	P42681
Weight	61 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: TXK polyclonal antibody detects endogenous levels of TXK protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304253	BS61497	50µl	$190.44		Add to Cart
BHA11304253	BS61497	100µl	$294.44		Add to Cart

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