Anti-TRAF2 Antibody BHA11300110

Mfr.No.	AP0694
Alternative Names	TNF receptor-associated factor 2 ; E3 ubiquitin-protein ligase TRAF2 ; Tumor necrosis factor type 2 receptor-associated protein 3 ; TRAF2 ; TRAP3
Categories	Primary Antibodies
Chromosome Location	9q34.3
Clonality	polyclonal
Description	Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily, which includes the FAS antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the N-terminus of Human TRAF2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: TRAF2 (S11) polyclonal antibody detects endogenous levels of TRAF2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 118% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.