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Home / Primary Antibodies / IHC Antibodies

Anti-TPX2 Antibody BHA11301724

SKU : BHA11301724

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Mfr.No.	BS3016
Alternative Names	Targeting protein for Xklp2 ; Differentially expressed in cancerous and non-cancerous lung cells 2 ; DIL-2 ; Hepatocellular carcinoma-associated antigen 519 ; Protein fls353 ; Restricted expression proliferation-associated protein 100 ; p100 ; TPX2 ; C20orf1 ; C20orf2 ; DIL2 ; HCA519
Antigen	TPX2
Categories	Primary Antibodies
Chromosome Location	20q11.21
Clonality	polyclonal
Description	TPX2 (targeting protein for Xklp2) is a microtubule-associated protein involved in targeting the motor protein Xklp2 to microtubules. Ran-GTP activates TPX2 for the chromatin-induced microbutule assembly during M phase. Aurora-A kinase associates with TPX2 at the spindle apparatus and may regulate TPX2 via phosphorylation during the spindle assembly. TPX2 appears to play a structural role in spindle formation. TPX2 activates Eg2 in a microtubuledependent manner by stimulating the phosphorylation and kinase activity of Eg2. TPX2 is inactivated by binding to importin α, a nuclear import factor. Finally, the suppression of TPX2 with RNA interference causes defects in microtubule organization during mitosis.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 300-345 of Human TPX2.
Reactivity	Human, Mouse
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9ULW0
Uniprot	Q9ULW0
Weight	88 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: TPX2 (Q330) polyclonal antibody detects endogenous levels of TPX2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301724	BS3016	50µl	$190.44		Add to Cart
BHA11301724	BS3016	100µl	$294.44		Add to Cart

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