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Home / Antibodies

Anti-TP53 Antibody BHA11300441

SKU : BHA11300441

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Mfr.No.	BS1275
Alternative Names	Cellular tumor antigen p53 ; Antigen NY-CO-13 ; Phosphoprotein p53 ; Tumor suppressor p53 ; TP53 ; P53
Antigen	TP53
Categories	Primary Antibodies
Chromosome Location	17p13.1
Clonality	polyclonal
Description	p53, a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor, upregulates growth arrest and apoptosisrelated genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus, yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 poly-ubiquitinates p53 for proteasome targeting. p53 fluctuates between latent and active (DNA-binding) conformations and is differentially activated through posttranslational modifications including phosphorylation and acetylation.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the N-terminus of Human p53.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P04637
Uniprot	P04637
Weight	43, 53 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: p53 (P27) pAbdetects endogenous levels of p53 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300441	BS1275	50µl	$190.44		Add to Cart
BHA11300441	BS1275	100µl	$294.44		Add to Cart

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