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Home / Antibodies

Anti-TNFAIP6 Antibody BHA11304163

SKU : BHA11304163

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Mfr.No.	BS61291
Alternative Names	Tumor necrosis factor-inducible gene 6 protein ; Hyaluronate-binding protein ; TNF-stimulated gene 6 protein ; TSG-6 ; Tumor necrosis factor alpha-induced protein 6 ; TNF alpha-induced protein 6 ; TNFAIP6 ; TSG6
Categories	Primary Antibodies
Chromosome Location	2q23.3
Clonality	polyclonal
Description	The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNFα and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNFα, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-α-inhibitor (IαI). TSG-6 potentiates the inhibitory effect of lαl on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and lαl can modulate the protease network and thus inhibit inflammation.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human TNFAIP6.
Reactivity	Human, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P98066
Uniprot	P98066
Weight	31 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3. Specificity: TNFAIP6 polyclonal antibody detects endogenous levels of TNFAIP6 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11304163	BS61291	50µl	$190.44		Add to Cart
BHA11304163	BS61291	100µl	$294.44		Add to Cart

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