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Home / Antibodies

Anti-SUPT4H1 Antibody BHA11303625

SKU : BHA11303625

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Mfr.No.	BS60490
Alternative Names	Transcription elongation factor SPT4 ; hSPT4 ; DRB sensitivity-inducing factor 14 kDa subunit ; DSIF p14 ; DRB sensitivity-inducing factor small subunit ; DSIF small subunit ; SUPT4H1 ; SPT4H ; SUPT4H
Categories	Primary Antibodies
Chromosome Location	17q22
Clonality	polyclonal
Description	SPT4 (also designated Suppressor of Ty4 and p14) and SPT5 (also designated DSIF p160) are highly conserved proteins from yeast to humans. Nuclear SPT4 and SPT5 are involved in both DRB (5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole)-mediated transcriptional inhibition as well as the activation of transcriptional elongation by the HIV-1 protein Tat. SPT4 binds SPT5 to form the DSIF (DRB-sensitivity-inducing factor) complex, which binds RNA polymerase II and directly regulates elongation. However, SPT5 protein in mitotic HeLa cells migrates more slowly on SDS-PAGE than does SPT5 isolated from interphase cells, as a result of enhanced SPT5 phosphorylation. The C-terminal CTR1 domain of SPT5 is the substrate for P-TEFb phosphorylation, which is critical for SPT5 function as a regulator of transcriptional elongation.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human SUPT4H1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P63272
Uniprot	P63272
Weight	13 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: SUPT4H1 polyclonal antibody detects endogenous levels of SUPT4H1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303625	BS60490	50µl	$190.44		Add to Cart
BHA11303625	BS60490	100µl	$294.44		Add to Cart

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