Anti-STK11 Antibody BHA11300073

Mfr.No.	AP0399
Alternative Names	Serine/threonine-protein kinase STK11 ; Liver kinase B1 ; LKB1 ; hLKB1 ; Renal carcinoma antigen NY-REN-19 ; STK11 ; LKB1 ; PJS
Categories	Primary Antibodies
Chromosome Location	19p13.3
Clonality	polyclonal
Description	LKB1, a member of the serine/threonine kinase family, is a tumor suppressor. Physically associates with p53, it regulates specific p53 dependent apoptosis pathways. LKB1 protein is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. Restoring LKB1 activity into cancer cell lines defective for its expression results in a G1 cell cycle arrest.Mutations in LKB1 gene are associated with Peutz Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 396-442 of Human LKB1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: LKB1 (R425)pAb detects endogenous levels of LKB1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.