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Home / Primary Antibodies / IHC Antibodies

Anti-SMG7 Antibody BHA11301167

SKU : BHA11301167

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Mfr.No.	BS2112
Alternative Names	C1orf16 ; EST1 like protein C ; EST1 telomerase component homolog C ; EST1C ; ever shorter telomeres 1C ; FLJ23717 ; SGA56M ; SMG 7
Antigen	SMG7
Categories	Primary Antibodies
Chromosome Location	1q25.3
Clonality	polyclonal
Description	In humans, NMD depends on RNA-dependent ATPase and 5' to 3' helicase UPF1, plus six other proteins designated SMG1, SMG5, SMG6, SMG7, UPF2 and UPF3. SMG5, SMG7 and UPF1 localize to cytoplasmic foci called P-bodies, while SMG5, SMG6 and SMG7 target UPF1 for dephosphorylation. SMG7 may also act as an adaptor in targeting mRNAs associated with phosphorylated UPF1 for degradation. SMG7 provides a link between the NMD pathway and mRNA degradation machinery by forming a complex with the proteins SMG5 and UPF1, interacting with them via its N-terminal domain, and targeting bound reporter transcripts for decay via its C-terminal domain. SMG7 contains a 14-3-3-like domain, and residues that bind phosphoserine-containing peptides in 14-3-3 proteins are conserved at the equivalent positions in SMG7.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 512-564 of Human SMG7.
Reactivity	Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q92540
Uniprot	Q92540
Weight	127 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: SMG7 (K548) polyclonal antibody detects endogenous levels of SMG7 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301167	BS2112	50µl	$190.44		Add to Cart
BHA11301167	BS2112	100µl	$294.44		Add to Cart

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