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Home / Antibodies

Anti-SLC6A12 Antibody BHA11303811

SKU : BHA11303811

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Mfr.No.	BS60695
Alternative Names	Sodium- and chloride-dependent betaine transporter ; BGT-1 ; Na(+)/Cl(-) betaine/GABA transporter ; Solute carrier family 6 member 12 ; SLC6A12
Antigen	SLC6A12
Categories	Primary Antibodies
Chromosome Location	12p13.33
Clonality	polyclonal
Description	BGT-1, also known as sodium- and chloride-dependent betaine transporter, SLC6A12 (solute carrier family 6 member 12) or Na(+)/Cl(-) betaine/GABA transporter, is a 614 amino acid protein. As a multi-pass membrane protein, BGT-1 localizes to liver, heart, skeletal muscle and placenta and is widely distributed in brain. BGT-1 has the typical structure of neurotransmitter transporters, with twelve transmembrane domains and a large extracellular loop between the third and fourth transmembrane domains. BGT-1 transports betaine and GABA, and may have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. BGT-1 is associated with mucus production in asthma, and could affect reversibility of lung function abnormalities in aspirin-intolerant asthma patients. BGT-1 displays significant functional differences from the other members of the GABA transporter family.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human SLC6A12
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P48065
Uniprot	P48065
Weight	69 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: SLC6A12 polyclonal antibody detects endogenous levels of SLC6A12 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303811	BS60695	50µl	$190.44		Add to Cart
BHA11303811	BS60695	100µl	$294.44		Add to Cart

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