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Home / Antibodies

Anti-SLC16A5 Antibody BHA11300111

SKU : BHA11300111

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Mfr.No.	AP0702
Alternative Names	Monocarboxylate transporter 6 ; MCT 6 ; Monocarboxylate transporter 5 ; MCT 5 ; Solute carrier family 16 member 5 ; SLC16A5 ; MCT5 ; MCT6
Categories	Primary Antibodies
Clonality	polyclonal
Description	Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT6 is highly expressed in the kidneys and is thought to have a specificity for bumetanide, a loop diuretic involved in the treatment of edema. The high substrate specificity of MCT6 suggests a possible role in therapeutic drug transport and trafficking across the plasma membrane.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 161-210 of Human SLC16A5.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	O15375
Uniprot	O15375
Weight	55 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: SLC16A5 (A193) polyclonal antibody detects endogenous levels of SLC16A5 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300111	AP0702	50µl	$190.44		Add to Cart
BHA11300111	AP0702	100µl	$294.44		Add to Cart

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