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Home / Antibodies

Anti-SLC16A3 Antibody BHA11301875

SKU : BHA11301875

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Mfr.No.	BS3331
Alternative Names	Monocarboxylate transporter 4 ; MCT 4 ; Solute carrier family 16 member 3 ; SLC16A3 ; MCT4
Antigen	SLC16A3
Categories	Primary Antibodies
Chromosome Location	17q25.3
Clonality	polyclonal
Description	Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs),which function as proton symports and are stereoselective for L-lactate.The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT1 is widely expressed and is the major form of MCTs in tumor cells and erythrocytes. MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 241-290 of Human MCT4.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O15427
Uniprot	O15427
Weight	49 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: MCT4 (F265) polyclonal antibody detects endogenous levels of MCT4 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301875	BS3331	50µl	$190.44		Add to Cart
BHA11301875	BS3331	100µl	$294.44		Add to Cart

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