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Home / Antibodies

Anti-SLC16A2 Antibody BHA11303008

SKU : BHA11303008

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Mfr.No.	BS5793
Alternative Names	Monocarboxylate transporter 8 ; MCT 8 ; Monocarboxylate transporter 7 ; MCT 7 ; MCT7 ; Solute carrier family 16 member 2 ; X-linked PEST-containing transporter ; MCT8 ; XPCT
Categories	Primary Antibodies
Chromosome Location	Xq13.2
Clonality	polyclonal
Description	Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiencey (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 152-197 of Human SLC16A2.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	P36021
Uniprot	P36021
Weight	63 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: SLC16A2 polyclonal antibody detects endogenous levels of SLC16A2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303008	BS5793	50µl	$190.44		Add to Cart
BHA11303008	BS5793	100µl	$294.44		Add to Cart

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