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Home / Antibodies

Anti-SH2D1A Antibody BHA11303630

SKU : BHA11303630

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Mfr.No.	BS60496
Alternative Names	SH2 domain-containing protein 1AAlternative name(s):Duncan disease SH2-proteinSignaling lymphocytic activation molecule-associated proteinShort name:SLAM-associated proteinT-cell signal transduction molecule SAPGene namesi Name:SH2D1A ; DSHP ; SAP
Categories	Primary Antibodies
Chromosome Location	Xq25
Clonality	polyclonal
Description	SH2D1A, also SH2 domain protein 1A, SAP and CD150/SLAM (signaling lymphocyte activation molecule)-associated protein, influences signaling pathways involving SLAM molecules at the interface between T and B cells. SH2D1A modulates SLAM by blocking the recruitment of tyrosine phosphatase SHP2 to the phosphorylated cytoplasmic domain of SLAM. SLAM activation mediates expansion of activated T cells during immune responses, induces production of interferon-© and changes the functional profile of subsets of T cells. SH2D1A is a hydrophilic, 128 amino acid protein that is 96% homologous to the mouse protein in both SH2 and tail domains. SH2D1A is present in all major subsets of T cells, including CD4+, CD45RO+, CD45RA+ and CD8+, but not in B cells. SH2D1A can interact via an SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of cell-surface receptors SLAM (CD150), CD84, CD229 (LY9) and CD244 (2B4).
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human SH2D1A.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	O60880
Uniprot	O60880
Weight	14 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. Specificity: SH2D1A polyclonal antibody detects endogenous levels of SH2D1A protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303630	BS60496	50µl	$190.44		Add to Cart
BHA11303630	BS60496	100µl	$294.44		Add to Cart

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