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Home / Antibodies

Anti-RTN4R Antibody BHA11303485

SKU : BHA11303485

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Mfr.No.	BS60346
Alternative Names	Reticulon-4 receptor ; Nogo receptor ; NgR ; Nogo-66 receptor ; RTN4R ; NOGOR ; UNQ330/PRO526
Categories	Primary Antibodies
Chromosome Location	22q11.21
Clonality	polyclonal
Description	CNS white matter is selectively inhibitory for axonal outgrowth. Nogo is an oligodendrocyte-specific member of the reticulon family and is a component of CNS white matter that prevents axonal regeneration in the adult CNS. Nogo is expressed by oligodendrocytes and associates primarily with the endoplasmic reticulum. The extracellular domain of Nogo, designated Nogo-66 inhibits axonal extension, but does not alter non-neuronal cell morphology. Expression of a brain-specific, leucine-rich-repeat protein with high affinity for Nogo-66, the Nogo-66 receptor (Nogo-R), is sufficient to impart Nogo-66 axonal inhibition to unresponsive neurons. Disruption of the interaction between Nogo-66 and Nogo-R potentially provides for enhanced recovery after human CNS injury. Nogo-R is widely expressed in the brain, with the highest levels of expression in the gray matter of the CNS. In addition, low levels of Nogo-R mRNA are expressed in heart and kidney.
Host	Rabbit
Immunogen	A synthetic peptide corresponding to residues in Human Nogo-R.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q9BZR6
Uniprot	Q9BZR6
Weight	52 kDa

Description	Product: 1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol. Specificity: Nogo-R polyclonal antibody detects endogenous levels of Nogo-R protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB

Description

WB

Dilution

WB	1:500-1:1000

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11303485	BS60346	50µl	$190.44		Add to Cart
BHA11303485	BS60346	100µl	$294.44		Add to Cart

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